Alberto Mantovani

Alberto Mantovani was born in Milan in 1948. He graduated (summa cum laude) in1973 in Medicine at the University of Milan and in 1976 he specialized in Oncology at the University of Pavia. From 1973 to 1975 he had a scholarship at the Laboratory of Immunology and Chemotherapy at the Mario negri Institute in Milano. From 1973 to 1976 he was visiting fellow at the Department of Tumor Immunology of the Chester Research Institute in Belmont (GB). In 1978-1979 he was visiting fellow at the Laboratory ofImmunodiagnosis, NIH, Bethesda (USA), with a Yamagiwa-Yoshida Scholarship ofthe UICC first and then with a NATO grant. From 1979 to 1981 he was Senior investigator, Department of Tumor Immunology and Chemotherapy, Istituto di Ricerche Farmacologiche "Mario Negri", Milan. In 1981 he became Chief of the Laboratory of Immunology, Istituto di Ricerche Farmacologiche "Mario Negri". From 1994 to 2001 he was full Professor of General Pathology, School of Medicine, University of Brescia, Italy.Since 1996 he is Head of the Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan.Since 2001 he is full Professor of General Pathology, School of Medicine, StateUniversity of Milan. In 1998 he won the Biotec award (Dompè); in 2000 he won the T.Bonazinga Award, SLB (Cambridge, MA, USA). Since 2000 is a member of the European Molecular Biology Organization (EMBO) and since 2002 he is a member ofthe Henry Kunkel Society.

His research centers mainly on molecular regulation mechanisms of leukocyte infiltration. More specifically his attention is focused on the molecular function and regulation circuits of the inflammatory cytokines. The first interest was the primaryinflammatory cytokine interleukin 1 (IL-1). In particular negative regulation circuits made up of type II decoy receptors. This molecule, membrane bound or released, acts as a molecular trap for the IL-1, constituting a unique system in biology. This paradigmwas subsequently generalized by other inflammatory cytokines. In addition, a new IL-1 antagonist receptor was identified and defined. In general these studies bring to light the complexity and uniqueness of IL-1 negative regulation mechanisms.A second line of work centers on the study of secondary cytokines known as chemokines. New molecules have been defined (for example, macrophage derived chemokines, MDC) and new cellular targets. Among these the study of dendrite and endothelial cells has been emphasized.In addition, the discovery that pro- and anti- inflammatory signals not only regulate the level of chemokine production but also the level of receptions offers a new level of understanding of how the system functions and possible targets for therapeutic interventions. Finally, his group has cloned the PTX3 (cDNA and genome, human and mouse), thefirst member of the long pentraxin family.